Synthesis of strontium ranelate was written by Xu, Yan;Su, Man;Qu, Chun-sheng. And the article was included in Qilu Yaoshi in 2012.Product Details of 58168-20-0 This article mentions the following:
The synthesis of strontium ranelate was studied. The strontium ranelate was synthesized from citric acid by decarboxylation, esterification, cyclization, alkylation, hydrolyzation and then salt formation. The structure of strontium ranelate was confirmed by IR, 1H-NMR, 13C-NMR and the total yield was approx. 41.4%. This synthesis route was simple with low cost and high purity, and it was suitable for industrial production In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Product Details of 58168-20-0).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile carbon shifts are in the range of 115â?25 ppm whereas in isonitriles the shifts are around 155â?65 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Product Details of 58168-20-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts