A bifunctionalized organic-inorganic hybrid silica: synergistic effect enhances enantioselectivity was written by Xiao, Wei;Jin, Ronghua;Cheng, Tanyu;Xia, Daquan;Yao, Hui;Gao, Fei;Deng, Boxin;Liu, Guohua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Category: nitriles-buliding-blocks This article mentions the following:
An imidazolium-based bifunctional heterogeneous catalyst exhibits excellent catalytic efficiency in asym. transfer hydrogenation of aromatic ketones in aqueous medium. The superior catalytic performance and the enhanced enantioselectivity is attributed to the synergistic effect of salient imidazolium phase-transfer function and the confined nature of the chiral organoiridium catalyst. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Category: nitriles-buliding-blocks).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts