Electrophilic Activation of [1.1.1]Propellane for the Synthesis of Nitrogen-Substituted Bicyclo[1.1.1]pentanes was written by Livesley, Sarah;Sterling, Alistair J.;Robertson, Craig M.;Goundry, William R. F.;Morris, James A.;Duarte, Fernanda;Aissa, Christophe. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 4-(Benzylamino)benzonitrile This article mentions the following:
Herein, the electrophilic activation of [1.1.1]propellane in a halogen bond complex was reported, which enabled its reaction with electron-neutral nucleophiles such as anilines/azoles to give nitrogen-substituted bicyclo[1.1.1]pentanes (BCP)s such as I [R = H, Ph, Bn, etc.; Ar = Ph, 4-CNPh, 3,5-di-FPh, etc.] that were prominent motifs in drug discovery. A detailed computational anal. indicated that the key halogen bonding interaction promotes nucleophilic attack without sacrificing cage stabilization. Overall, this work rehabilitates electrophilic activation of [1.1.1]propellane as a valuable strategy for accessing functionalised BCPs. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Safety of 4-(Benzylamino)benzonitrile).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Safety of 4-(Benzylamino)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts