A new synthesis of 4-amino-2-quinolinones was written by Bergman, Jan;Brynolf, Anna;Vuorinen, Eino. And the article was included in Tetrahedron in 1986.Recommanded Product: 68385-95-5 This article mentions the following:
Addition of Grignard or organolithium reagents to N-(α-haloacyl)-N-alkylsubstituted anthranilonitriles, e.g. N-(2-bromopropionyl)-N-methyl-2-cyanoaniline, induced anion formation followed by cyclization to 4-amino-2-quinolinones, e.g. 4-amino-1,3-dimethyl-2-quinolinone (I). Substrates lacking α-hydrogen atoms, such as N-(α-bromoisobutyryl)-2-cyanoaniline, also yielded 3,3-dimethylquinolinedione by cyclization. In these cases the initial step is a halogen-metal exchange reaction. In the experiment, the researchers used many compounds, for example, 2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5Recommanded Product: 68385-95-5).
2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 68385-95-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts