Iridium-catalyzed α-alkylation of acetonitrile with primary and secondary alcohols was written by Sawaguchi, Takuya;Obora, Yasushi. And the article was included in Chemistry Letters in 2011.Application In Synthesis of 2-Cyclohexylacetonitrile This article mentions the following:
Acetonitrile is successfully alkylated with primary and secondary alcs. in the presence of t-BuOK using [Ir(OH)(cod)]2 as a catalyst. This method provides a very clean and atom-economical convenient direct route to substituted nitriles, which are very important raw materials in organic and industrial chem. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7Application In Synthesis of 2-Cyclohexylacetonitrile).
2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application In Synthesis of 2-Cyclohexylacetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts