Evaluation of Novel Synthetic Methods for the Preparation of the Sodium Channel Inhibitor, GW273225X was written by Walker, Matthew D.;Albinson, F. David;Clark, Hugh F.;Clark, Stacy;Henley, Nicholas P.;Horan, Richard A. J.;Jones, Chris W.;Wade, Charles E.;Ward, Richard A.. And the article was included in Organic Process Research & Development in 2014.Product Details of 3218-45-9 This article mentions the following:
The evaluation of efficient synthetic methods for the preparation of (R)-2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethylpyrimidine (GW273225X, I), is described. The initial synthesis using Et fluoroacetate was evaluated against three alternative routes using either nucleophilic fluorination, electrophilic fluorination, or sodium fluoroacetate. In the experiment, the researchers used many compounds, for example, 2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9Product Details of 3218-45-9).
2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Product Details of 3218-45-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts