Palladium Catalyzed Distal meta-C-H Functionalization of Arylacetic Acid Derivatives was written by Srinivas, Dasari;Satyanarayana, Gedu. And the article was included in Organic Letters in 2021.Application In Synthesis of 2-(4-Methoxyphenyl)-2-methylpropanenitrile This article mentions the following:
Herein, meta-C-H olefination of phenylacetic acid derivatives I [R1 = R2 = Me, Et; R1 = H, R2 = Me; R1R2 = (CH2)4; R3 = H, 3-Me, 4-MeO, 4-Br, 3,4-Cl2, etc.] with alkenes R4CH:CHR5 (R4 = H, R5 = MeO2C, EtO2C, Me2NCO, MeSO2, 4-O2NC6H4, etc.; R4 = R5 = EtO2C; etc.) for the synthesis of arylacrylates and analogs II by tethering with a simple nitrile-based template through palladium catalysis has been presented. Notably, the versatility of the method has been evaluated with a wide range of phenylacetic acid derivatives for accomplishing the meta-olefination products in fair to excellent yields with outstanding selectivities under milder conditions. Significantly, the present strategy was successfully exemplified for the synthesis of drugs/natural product analogs, such as naproxen, ibuprofen, paracetamol, and cholesterol. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Application In Synthesis of 2-(4-Methoxyphenyl)-2-methylpropanenitrile).
2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Application In Synthesis of 2-(4-Methoxyphenyl)-2-methylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts