9-Amino-1,2,3,4-tetrahydroacridin-1-ols. Synthesis and evaluation as potential Alzheimer’s disease therapeutics was written by Shutske, Gregory M.;Pierrat, Frank A.;Kapples, Kevin J.;Cornfeldt, Michael L.;Szewczak, Mark R.;Huger, Francis P.;Bores, Gina M.;Haroutunian, Vahram;Davis, Kenneth L.. And the article was included in Journal of Medicinal Chemistry in 1989.Safety of 2-Amino-4-(trifluoromethyl)benzonitrile This article mentions the following:
The synthesis of a series of 9-amino-1,2,3,4-tetrahydroacridin-1-ols is reported. These compounds are related to tacrine. They inhibit acetylcholinesterase in vitro and are active in a model that may be predictive of activity in Alzheimer’s disease; the scopolamine-induced impairment of 24-h memory of a passive dark-avoidance paradigm in mice. Two compounds, (±)-9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate (HP-029) and (±)-9-(benzylamino)-1,2,3,4-tetrahydroacridin-1-ol maleate (HP-128), were also active in reversing the deficit in 72-h retention of a (1-trial dark-avoidance task in rats, induced by ibotenic acid lesions in the nucleus basalis magnocellularis. In addition, HP-128 showed potent in vitro inhibition of the uptake of radiolabeled noradrenaline and dopamine (IC50 = 0.070 μM and 0.30 μM, resp.). HP-029 and HP-128, which showed less acute toxicity in both rats and mice than tacrine, are in phase II and phase I clin. trials, resp., for Alzheimer’s disease. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Safety of 2-Amino-4-(trifluoromethyl)benzonitrile).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Safety of 2-Amino-4-(trifluoromethyl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts