Microwave accelerated synthesis of 2-aminothiophenes in ionic liquid via three component Gewald reaction was written by Chavan, Sunil S.;Pedgaonkar, Yogesh Y.;Jadhav, Ananda J.;Degani, Mariam S.. And the article was included in Indian Journal of Chemistry in 2012.Electric Literature of C8H8N2S This article mentions the following:
Microwave-accelerated synthesis of substituted 2-aminothiophenes by a 3-component Gewald reaction using a basic ionic liquid, 1,1,3,3-tetramethylguanidine lactate [TMG][Lac], as solvent as well as catalyst was developed. The products are obtained in good to high yields and the ionic liquid is reusable over several cycles without significant loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Electric Literature of C8H8N2S).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Electric Literature of C8H8N2S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts