Site-selectivity in the cyanation of 3-substituted pyridine 1-oxides with trimethylsilanecarbonitrile was written by Sakamoto, Takao;Kaneda, Sohichi;Nishimura, Sumiko;Yamanaka, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Quality Control of 4-methoxypicolinonitrile This article mentions the following:
Treatment of pyridine 1-oxides I (R = Br, Cl, F, OMe, NMe2, Me, Et, Ph, CONEt2, CO2Et, cyano) with Me3SiCN gave 2- and 6-cyanopyridines II and III. The II – III ratio was strongly influenced by R, with II being the only product when R = F, OMe, NMe2. Nitropyridine 1-oxides underwent deoxygenation but not cyanation with Me3SiCN. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Quality Control of 4-methoxypicolinonitrile).
4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Quality Control of 4-methoxypicolinonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts