Theoretical study of the relative acidities of substituted phenylacetonitrile was written by Julg, Andre;Fournon, Claire. And the article was included in Journal de Chimie Physique et de Physico-Chimie Biologique in 1960.Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile This article mentions the following:
The L.C.A.O.-M.O. method is used to calculate the energies of PhCH2CN and (PhCHCN)– and of derivatives substituted in the nucleus. The difference between the ion and the undissociated mol. is taken as a measure of the acidity. Values for the Coulomb and exchange integrals are chosen from the literature. The following comps. RCH2CN are arranged according to decreasing acidity (R and relative dissociation energy in terms of β); p-NO2C6H4, 7.41; p-BrC6H4, 7.35; Ph, 7.34; 3,5-dimethylphenyl, 7.34; 2,6-dibromophenyl, 7.25; 3,5-dibromophenyl, 7.22; 2,4,6-trimethylphenyl, 7.20; H, 6.56. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile).
2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts