Related Products of 1897-52-5, These common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of compound 2.2. Compound 2.1 (5 g, 35.97 mmol, 1.00 eq), NH4C1 (2.11 g, 39.56 mmol, 1.1 eq) were suspended in toluene (100ml). A solution of trimethylaluminium (2.0 M, 19.5 ml, 39.56 mmol, 1.1 eq) was added dropwise to the above reaction mixture at room temperature. The mixture was stirred for one hour at ambient temperature and subsequently refluxed for 16 hours. After completion of the reaction, toluene was evaporated and residue was diluted with 10% methanol in CH2C12 (lOOmL). Silica gel (5.0 g) was added mixture and stirred for 30 minutes at ambient temperature. After 30 minutes, slurry was filtered and washed with CH2Cl2/methanol. The filtrate was concentrated under vacuum at 45 C to afford the crude material which was purified using trituration with 20% ethyl acetate in hexane (50ml). The solid obtained was filtered off and dried under vacuum to afforded pure compound 2.2 (4.5 g, 80.35 %). LCMS: 99.27%. MS (ES): m/z 157.0 (M+H)+.
The synthetic route of 1897-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts