Rates and equilibriums for the interaction of cyanonitrothiophene derivatives with the methoxide ion in methanol solution was written by Doddi, Giancarlo;Illuminati, Gabriello;Stegel, Franco. And the article was included in Tetrahedron Letters in 1973.Recommanded Product: 4-Nitrothiophene-2-carbonitrile This article mentions the following:
Addition of MeO- to 4-cyano-2-nitrothiophene and 2,4-dinitrothiophene, in MeOH solution gave Meisenheimer adducts of type (I, R = CN, NO2). However, 2-cyano-4-nitrothiophene gave Me 4-nitro-2-thiophenecarboximidate, the Meisenheimer adduct being formed on solution of the solid in Me2SO. Normal Meisenheimer adducts with MeO- in MeO-H solution were formed by 2-cyano-5-methoxy-4-nitrothiophene and the 2,4-dinitro analog. Kinetic and equilibrium constants for the adduct formation were determined by visible and NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Recommanded Product: 4-Nitrothiophene-2-carbonitrile).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Recommanded Product: 4-Nitrothiophene-2-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts