Synthesis and SAR study of potent and selective PI3Kδ inhibitors was written by Bui, Minna;Hao, Xiaolin;Shin, Youngsook;Cardozo, Mario;He, Xiao;Henne, Kirk;Suchomel, Julia;McCarter, John;McGee, Lawrence R.;San Miguel, Tisha;Medina, Julio C.;Mohn, Deanna;Tran, Thuy;Wannberg, Sharon;Wong, Jamie;Wong, Simon;Zalameda, Leeanne;Metz, Daniela;Cushing, Timothy D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Quality Control of 4-Amino-6-chloropyrimidine-5-carbonitrile This article mentions the following:
2,3,4-Substituted-quinolines such as I were found to be potent inhibitors of PI3Kδ in both biochem. and cellular assays with good selectivity over three other class I PI3K isoforms. Some of those analogs showed favorable pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4Quality Control of 4-Amino-6-chloropyrimidine-5-carbonitrile).
4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Quality Control of 4-Amino-6-chloropyrimidine-5-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts