Facile Synthesis of 2-Aminothiophenes Using NaAlO2 as an Eco-Effective and Recyclable Catalyst was written by Bai, Rongxian;Liu, Ping;Yang, Jian;Liu, Changhui;Gu, Yanlong. And the article was included in ACS Sustainable Chemistry & Engineering in 2015.Product Details of 70291-62-2 This article mentions the following:
Substituted 2-aminothiophenes were synthesized through Gewald reaction by using an easily available solid base catalyst, sodium aluminate. Cost-effectiveness, mild and environmentally benign conditions, and excellent catalytic performance are the features of this system. Furthermore, the NaAlO2 catalyst can be swimmingly recovered and reused in this reaction. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Product Details of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Product Details of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts