Malancona, Savina et al. published their research in ACS Medicinal Chemistry Letters in 2020 | CAS: 36057-44-0

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Formula: C7H6N2O

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein was written by Malancona, Savina;Mori, Mattia;Fezzardi, Paola;Santoriello, Marisabella;Basta, Andreina;Nibbio, Martina;Kovalenko, Lesia;Speziale, Roberto;Battista, Maria Rosaria;Cellucci, Antonella;Gennari, Nadia;Monteagudo, Edith;Di Marco, Annalise;Giannini, Alessia;Sharma, Rajhans;Pires, Manuel;Real, Eleonore;Zazzi, Maurizio;Dasso Lang, Maria Chiara;De Forni, Davide;Saladini, Francesco;Mely, Yves;Summa, Vincenzo;Harper, Steven;Botta, Maurizio. And the article was included in ACS Medicinal Chemistry Letters in 2020.Formula: C7H6N2O This article mentions the following:

The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escape the drug resistance (DR) that emerged following the highly active antiretroviral therapy (HAART) treatment. On the basis of our previous research, nordihydroguaiaretic acid 1 acts as a NC inhibitor showing moderate antiviral activity and suboptimal drug-like properties due to the presence of the catechol moieties. A bioisosteric catechol replacement approach led us to identify the 5-dihydroxypyrimidine-6-carboxamide substructure as a privileged scaffold of a new class of HIV-1 NC inhibitors. Hit validation efforts led to the identification of optimized analogs, as represented by compound 28, showing improved NC inhibition and antiviral activity as well as good ADME and PK properties. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Formula: C7H6N2O).

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Formula: C7H6N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts