Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents was written by Li, Xinbao;Han, Shuo;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2016.Synthetic Route of C12H14N2O4S This article mentions the following:
The solubility of Et 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate (ACET) in binary (acetone + methanol), (acetone + ethanol), (acetone + 1-butanol) and (acetone + isopropanol) solvent mixtures was investigated by the isothermal dissolution equilibrium method under 101.3 kPa. This study was carried out at different mass fractions of acetone ranging from 0.1 to 0.9 at T = (273.15-318.15) K. For the nine groups with each solvent mixture studied, the solubility of ACET in the mixed solutions increased with increasing temperature and mass fraction acetone. At the same temperature and mass fraction of acetone, the solubility of ACET was greater in (acetone + methanol) than in the other three solvent mixtures The exptl. solubility values were correlated by three co-solvency models (Jouyban-Acree model, van’t Hoff-Jouyban-Acree model and Apelblat- Jouyban-Acree model). The relative average deviations (RAD) and the root-mean-square deviations (RMSD) were all less than 1.49 × 10-2 and 8.99 × 10-4, resp. The Apelblat-Jouyban-Acree model provided best representation of the exptl. solubility Furthermore, the standard molar enthalpy of the ACET during the dissolving process (ΔsolHo) was also derived in this work, and the results showed that the dissolution process is endothermic. The exptl. solubility and the models used in this work would be helpful in purifying of ACET from its crude mixtures In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Synthetic Route of C12H14N2O4S).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Synthetic Route of C12H14N2O4S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts