Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines was written by Azouzi, Karim;Bruneau-Voisine, Antoine;Vendier, Laure;Sortais, Jean-Baptiste;Bastin, Stephanie. And the article was included in Catalysis Communications in 2020.Formula: C9H9NO This article mentions the following:
A series of com. available chiral amino-phosphines, in combination with Mn(CO)5Br, was evaluated for the asym. reduction of ketones to secondary alcs. RCH(OH)R1 [R = c-hexyl, Ph, 1-naphthyl, etc.; R1 = Me, Et, i-Pr, etc.] using isopropanol as hydrogen source. With the most selective ligand, the corresponding manganese complex was synthesized and fully characterized. A series of ketones was hydrogenated in the presence of 0.5 mol% of the manganese pre-catalyst affording the chiral alcs. in high yields with enantiomeric excesses up to 99%. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Formula: C9H9NO).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Formula: C9H9NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts