Immobilization of chiral Rh catalyst on glass and application to asymmetric transfer hydrogenation of aryl ketones in aqueous media was written by Cheng, Tan-Yu;Zhuang, Jing-Lan;Yao, Hui;Zhang, Huai-Sheng;Liu, Guo-Hua. And the article was included in Chinese Chemical Letters in 2014.Reference of 101219-69-6 This article mentions the following:
A chiral catalyst, Cp*RhTsDPEN (Cp* = pentamethylcyclopentadiene, TsDPEN = substituted N-phenylsulfonyl-1,2-diphenylethylenediamine), was synthesized and immobilized at the surface of glass. The immobilized catalyst exhibited good catalytic efficiency for asym. transfer hydrogenation of aromatic ketones in water with HCO2Na as hydrogen source. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Reference of 101219-69-6).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Reference of 101219-69-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts