Cyclopropenone-Catalyzed Direct Conversion of Aldoximes and Primary Amides into Nitriles was written by Rai, Ankita;Yadav, Lal Dhar S.. And the article was included in European Journal of Organic Chemistry in 2013.Formula: C6H5NS This article mentions the following:
Efficient conversion of aldoximes and primary amides into nitriles by employing cyclopropenone as an organocatalyst is reported. The reaction proceeds smoothly under mild conditions with 5 mol-% catalyst loading to afford nitriles in excellent yields (78-94 %) in a single operation. This method is equally applicable to both aldoximes and primary amides bearing aromatic, heterocyclic, and aliphatic moieties. The convenient and catalytic procedure widens the scope of the utilization of cyclopropenones in organic synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiophene-2-carbonitrile (cas: 55406-13-8Formula: C6H5NS).
3-Methylthiophene-2-carbonitrile (cas: 55406-13-8) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Formula: C6H5NS
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts