Insight into and practical application of pH-controlled asymmetric transfer hydrogenation of aromatic ketones in water was written by Wu, Xiaofeng;Li, Xiaoguang;King, Frank;Xiao, Jianliang. And the article was included in Angewandte Chemie, International Edition in 2005.Application of 101219-69-6 This article mentions the following:
Much faster, more enantioselective, and more-productive catalysis was attained in the asym. transfer hydrogenation of aromatic ketones with the Noyori-Ikariya Ru-Ts-dpen catalyst in water under slightly basic conditions. At low pH values, the reaction was much less efficient and appears to operate through a different mechanism. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Application of 101219-69-6).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Application of 101219-69-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts