Structure-activity relationships of novel potent MurF inhibitors was written by Gu, Yu Gui;Florjancic, Alan S.;Clark, Richard F.;Zhang, Tianyuan;Cooper, Curt S.;Anderson, David D.;Lerner, Claude G.;McCall, J. Owen;Cai, Yingna;Black-Schaefer, Candace L.;Stamper, Geoffrey F.;Hajduk, Philip J.;Beutel, Bruce A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Related Products of 70291-62-2 This article mentions the following:
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC50 = 22 ∼ 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Related Products of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts