2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors was written by Patel, Leena;Chandrasekhar, Jayaraman;Evarts, Jerry;Haran, Aaron C.;Ip, Carmen;Kaplan, Joshua A.;Kim, Musong;Koditek, David;Lad, Latesh;Lepist, Eve-Irene;McGrath, Mary E.;Novikov, Nikolai;Perreault, Stephane;Puri, Kamal D.;Somoza, John R.;Steiner, Bart H.;Stevens, Kirk L.;Therrien, Joseph;Treiberg, Jennifer;Villasenor, Armando G.;Yeung, Arthur;Phillips, Gary. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: 2-Amino-4,6-dichloropyrimidine-5-carbonitrile This article mentions the following:
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematol. malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and structural strategies were employed to mitigate aldehyde oxidase mediated metabolism This medicinal chem. effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis. In the experiment, the researchers used many compounds, for example, 2-Amino-4,6-dichloropyrimidine-5-carbonitrile (cas: 1277179-33-5Recommanded Product: 2-Amino-4,6-dichloropyrimidine-5-carbonitrile).
2-Amino-4,6-dichloropyrimidine-5-carbonitrile (cas: 1277179-33-5) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Recommanded Product: 2-Amino-4,6-dichloropyrimidine-5-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts