Nickel Catalyzed Regiodivergent Cross-Coupling Alkylation of Aryl Halides with Redox-Active Imines was written by Huang, Long;Kancherla, Rajesh;Rueping, Magnus. And the article was included in ACS Catalysis in 2022.Formula: C11H13N This article mentions the following:
Herein, a visible light nickel-catalyzed protocol for the deaminative cross-coupling of redox-active imines with various electrophiles that allow for the rapid construction of C(sp3) enriched arene Ar(t-Bu)/Me2CH2Ar [Ar = 4-NCC6H4, 4-Ph(CO)C6H4, 3-NCC6H4, etc.]/AcAr [Ar = 4-((Me)2(Et))CC6H4, 4-(C(O)OEtCH2(Me)2)CC6H4, 4-((PhCH2CH2)(Me)2)CC6H4, etc.] in a regiodivergent manner. Key to the success of this protocol was the combination of a readily available organic photocatalyst and a Lewis acid additive. As an addnl. approach to alkylarenes, also showcased that the nature of electrophiles dictates the regiochem. outcome. In the experiment, the researchers used many compounds, for example, 3-(tert-Butyl)benzonitrile (cas: 154532-34-0Formula: C11H13N).
3-(tert-Butyl)benzonitrile (cas: 154532-34-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Formula: C11H13N
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts