Divergent synthesis of 2-methylthioindole and 2-unsubstituted indole derivatives mediated by SOCl2 and dimethyl/diethyl sulfoxides was written by Zhang, Jingran;Zhang, Beibei;He, Jiaxin;Shi, Haofeng;Du, Yunfei. And the article was included in Organic & Biomolecular Chemistry in 2022.Application of 1483-54-1 This article mentions the following:
A metal-free divergent synthesis of indole compounds dependent on a reagent via intramol. C(sp2)-H amination was described. The reaction of 2-vinylanilines with DMSO/SOCl2 at 70 ° was found to give 2-thiomethylindoles, while replacing DMSO with di-Et sulfoxide afforded 2-unsubstituted indoles in a highly selective manner. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Application of 1483-54-1).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Application of 1483-54-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts