Thienopyridines: nitric oxide synthase inhibitors with potent In vivo activity was written by Beaton, H.;Boughton-Smith, N.;Hamley, P.;Ghelani, A.;Nicholls, D. J.;Tinker, A. C.;Wallace, A. V.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Related Products of 55406-13-8 This article mentions the following:
5-Substituted 7-amino-4,5-tetrahydrothieno[2,3-c]pyridines and 6-substituted 4-amino-6,7-dihydrothieno[3,2-c]pyridines were shown to be exceptionally potent inhibitors of inducible and neuronal nitric oxide synthase. Selectivity and potency could be modulated by variation of the 5- or 6-substituent. In the experiment, the researchers used many compounds, for example, 3-Methylthiophene-2-carbonitrile (cas: 55406-13-8Related Products of 55406-13-8).
3-Methylthiophene-2-carbonitrile (cas: 55406-13-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Related Products of 55406-13-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts