Guanidine derivatives. XVI. Synthesis of alkylated 4-alkoxyphenylacetonitriles and substituted guanidines was written by Ovsepyan, T. R.;Petrosyan, A. S.;Aroyan, A. A.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1973.Recommanded Product: 5351-07-5 This article mentions the following:
4-ROC6H4CR1R2CN (I; R,R2 = Me, Et, Pr; R1 = H, Me, Et, Pr) were prepared (38.3-70.2%) by the reaction of 4-ROC6H4CH2CN with NaNH2 and the corresponding R1X and R2X (X = halo). Catalytic reduction of I over Ni-Cr2O3 gave 64.2-85.5% 4-ROC6H4CR1R2CH2NH2 (II). Reaction of II with MeSC(:NH)NH2.5H2SO4 gave, 36.7-74.1% 4-ROC6H4CR1R2CH2NHC(:NH)NH2.5H2SO4. 4-ROC6H4CH2NHCSNHNHC(:NH)NH2.HNO3 (R = Me, Et, Pr) were prepared (13.9-19.0%) by the reaction of 4-ROC6H4CH2NCS with H2NNHC(:NH)NH2.HNO3. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Recommanded Product: 5351-07-5).
2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 5351-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts