A high-yielding preparation of β-keto nitriles was written by Ji, Yaohui;Trenkle, William C.;Vowles, James V.. And the article was included in Organic Letters in 2006.HPLC of Formula: 4435-14-7 This article mentions the following:
β-Keto nitriles are important precursors for a wide variety of biol. active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide β-keto nitriles is reported. Thus, reaction of PhCH2CH2CN with PhCO2Et in THF containing EtCMe2OH K salt at room temperature for 10 min gave 95% PhCH2CH(CN)COPh. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7HPLC of Formula: 4435-14-7).
2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 4435-14-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts