Electric Literature of 1080-74-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1080-74-6 as follows.
A solution of intermediate 67 (135 mg, 0.130 mmol) in chloroform (10 cm3) and pyridine (0.75 cm3) is degassed for 10 minutes with nitrogen. 2-(3- Oxo-indan-1 -ylidene)-malononitrile (180 mg, 0.91 mmol) is added in one portion and the reaction mixture is stirred at 23 C for 150 minutes. Methanol (15 cm3) is added and the obtained precipitate is collected by filtration and washed with methanol (3 x 10 cm3). The solid is filtered through a pad of silica (40-60 petrol:dichloromethane; 2:3). Concentration in vacuo followed by trituration in refluxing acetone (20 cm3) and then in a 3:1 mixture of acetone:chloroform (40 cm3) gives compound 1 15 (144 mg, 79%) as a dark blue powder. 1H NMR (400 MHz, CDCIs) 8.84 (2H, s), 8.61 – 8.67 (2H, m), 7.84 – 7.90 (2H, m), 7.63 – 7.72 (6H, m), 7.13 – 7.21 (8H, m), 6.83 – 6.90 (8H, m), 3.81 (4H, m), 3.72 (4H, m), 1 .78 – 1 .92 (4H, m, J 6.6), 1 .56 (4H, m), 1 .26 (4H, m), 1 .00 (12H, d, J 6.7), 0.94 (12H, t, J 7.5).
According to the analysis of related databases, 1080-74-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
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