Application of 1558-81-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1558-81-2, name is Ethyl 1-Cyano-1-cyclopropanecarboxylate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To concentrated sulfuric acid (102 mL) was added 1-cyano-cyclopropanecarboxylic acid ethyl ester (60 g, 0.43 mol) dropwise followed by 2-methylpentan-2,4-diol (52 g, 0.44 mmol) dropwise at 0 C. The mixture was stirred for an additional 1 h at 0 C. then poured onto ice-water. The aqueous phase was washed with AcOEt (3¡Á200 mL) and then basified to pH 12 with 10 M NaOH. The resulting mixture was extracted with EtOAc (3¡Á500 mL). The combined organic layer was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel to give 1-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl)-cyclopropanecarboxylic acid ethyl ester (65 g, yield: 63.2%). 1H NMR (CDCl3 400 MHz): delta4.21-4.06 (m, 311), 1.73-1.69 (m, 1H), 1.40-1.10 (m, 1711)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-Cyano-1-cyclopropanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.; US2014/107340; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts