Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 20099-89-2
Step-I: 4-(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzonitrile (XI-10-I) A mixture of 2,6-diaminopyrimidin-4-ol (1 g, 7.93 mmol) and NaOAc (0.846 g, 10.31 mmol) in water (180 mL) was heated to 100 C. for 20 minutes. To this was added a suspension of 4-(2-bromoacetyl)benzonitrile (2.2 gm, 8.73 mmol) [prepared according to procedure mentioned in J. Med. Chem., 2011, 54(12), 4042-4056] in MeOH (25 mL) and heated overnight at 100 C. After completion of reaction, the reaction mixture was cooled to 0 C. Resultant solid product was filtered off and dried under reduced pressure to provide title compound XI-10-I (1.2 g, 100%). LCMS: m/z 252 (M+1)+.
According to the analysis of related databases, 20099-89-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Thakkar, Mahesh; Koul, Summon; Bhuniya, Debnath; Mookhtiar, Kasim; Kurhade, Santosh; Munot, Yogesh; Mengawade, Tanaji; Kulkarni, Bheemashankar A.; US2015/64196; (2015); A1;,
Nitrile – Wikipedia,
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