Electric Literature of 1080-74-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a degassed solution of compound 10-5 (150 mg, 0.1 1 mmol) and pyridine (0.6 cm3) in anhydrous chloroform (40 cm3) at 0 C was added a degassed solution of 2-(3-oxo-indan-1 -ylidene)-malononitrile (86 mg, 0.440 mmol) in anhydrous chlorofornn (8 cm3). The resulting solution was then degassed for a further 30 minutes. The ice bath was removed and the reaction mixture warmed to 23 C and stirred for 18 hours. The reaction mixture was diluted with acetonitrile (150 cm3) and stirred for 1 hour. The solid collected by filtration and washed with acetonitrile (100 cm3) and methanol (100 cm3). The crude was then purified by column chromatography (dichloromethane) followed by trituration in acetonitrile (100 cm3) to give compound 1 1 (183 mg, 97%) as a dark green solid. 1H- NMR (400 MHz, CD2CI2) 0.67 – 0.80 (24H, m), 1.1 1 – 1.23 (48H, m), 1.36 – 1.55 (16H, m), 2.43 (16H, t, J 7.7), 6.78 – 6.92 (12H, m), 7.63 – 7.74 (4H, m), 7.78 – 7.87 (4H, m), 8.60 (2H, d, J 7.3), 8.80 (2H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; HEARD, Kane; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (260 pag.)WO2019/52935; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts