Application of 34916-10-4,Some common heterocyclic compound, 34916-10-4, name is 4-Oxo-cyclohexanecarbonitrile, molecular formula is C7H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 250-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 119.1 (10 g, 81.20 mmol, 1.00 equiv), methanol (100 mL). This was followed by the addition of NaBH4 (1.52 g, 40.18 mmol, 0.50 equiv) at 0 C. in a water/ice bath. The resulting solution was stirred for 1 h at room temperature. The reaction was then quenched by the addition of 20 mL of NH4Cl (aq). The resulting solution was extracted with 2¡Á100 mL of ethyl acetate and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 10.02 g (99%) of 119.2 as colorless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Oxo-cyclohexanecarbonitrile, its application will become more common.
Reference:
Patent; Gilead Apollo, LLC; Ghosh, Shomir; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Leit De Moradei, Silvana Marcel; (290 pag.)US2017/166584; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts