Application of 6629-04-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6629-04-5, name is N-Cyanoacetylurethane belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Aniline (10.3 g, 0.11 mol) and hydrochloric acid (45 mL, 0.56 mol) were added to water (400 mL). The mixture was stirred and cooled down to 0 C. To the mixture was added dropwise an aqueous solution of NaNO2 (7.73 g, 0.11 mol) while controlling the temperature between 0 and 5 C. After the dropwise addition, the reaction was conducted at a temperature between 0 and 5 C. for 30 min. The obtained solution was reserved for future use. Intermediate a and sodium acetate (80 g, 0.98 mol) were added to ethanol (400 mL). The mixture was stirred and cooled down to 0 C. To the solution of Intermediate a was added dropwise the reserved solution while controlling the temperature between 0 and 5 C. After the dropwise addition, the reaction was conducted at a temperature between 0 and 5 C. for 2 h. The reaction is filtered by suction. The filtered cake was washed with water and dried to produce an orange solid (21.5 g) in a yield of 91.1%.
The synthetic route of N-Cyanoacetylurethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; XU, Hua; US2013/252958; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts