Synthetic Route of 25309-65-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25309-65-3, name is 4-Ethylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 27 Preparation of 2-(p-ethylphenyl)-5(6)-methoxybenzimidazole 5.0 g. of p-ethylbenzonitrile in 40 ml. of methanolic hydrochloric acid was stirred at room temperature overnight. The reaction mixture was diluted with water, neutralized with sodium carbonate and extracted with n-hexane. The extract was evaporated in vacuo to remove n-hexane. The remaining alkoxyimine compound was dissolved in methanol and 4.7 g. of p-anisidine was added thereto. The mixture was warmed for 30 minutes and evaporated in vacuo to remove methanol, whereby N-(p-methoxyphenyl)-4-ethylbenzamidine was recovered. This product was dissolved in water and then acidified with hydrochloric acid.
The synthetic route of 4-Ethylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kanebo, Ltd.; US4188486; (1980); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts