Some common heterocyclic compound, 22972-63-0, name is 2-(3,5-Dimethoxyphenyl)-2-methylpropanenitrile, molecular formula is C12H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C12H15NO2
PREPARATION E 2-Methyl-2-(3,5-dihydroxyphenyl)-5-phenylpentane To a solution of the Grignard reagent prepared from 2-phenylbromoethane (5.5 g.), magnesium (0.8 g.) and dry ether (60 ml.) is added a solution of 2-methyl-2-(3,5-dimethoxyphenyl)propionitrile (2.75 g.) in dry ether (20 ml.). The ether is distilled off and replaced by dry benzene (50 ml.) and the mixture refluxed for 48 hours. It is then decomposed by careful treatment with dilute sulfuric acid and heated on a steam bath for 1 hour. The mixture is then extracted with ether, the extract dried (MgSO4) and concentrated to an oil. Distillation of the oil in vacuo affords 2-methyl-2-(3,5-dimethoxyphenyl)-5-phenyl-3-pentanone; b.p. 168 C./0.2 mm. (Yield: 2.32 g., 60%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 22972-63-0, its application will become more common.
Reference:
Patent; Pfizer Inc.; US4143139; (1979); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts