Reference of 64248-62-0, The chemical industry reduces the impact on the environment during synthesis 64248-62-0, name is 3,4-Difluorobenzonitrile, I believe this compound will play a more active role in future production and life.
40 mL of N,N-dimethylformamide was placed in a 250 mL four-necked flask.R-(+)-2-(4-hydroxyphenoxy)propionic acid butyl ester 34g (0.14 mol),3,4-difluorobenzonitrile 24g (0.168mol),Phase transfer catalyst 18-crown-6 0.15g, TEBA 0.15g,With stirring, 58 g (0.42 mol) of potassium carbonate was added, and a large amount of bubbles were generated;Then the temperature was raised to 85-90 C, the reaction was kept for 3 hours, and the sample was analyzed by HPLC.R-(+)-2-(4-hydroxyphenoxy)propionic acid butyl ester <0.5%, the reaction was completed.Filtration, distilling off the solvent under reduced pressure, and cooling to room temperature with 150 mL of water.The temperature is raised to 60-70 C, the mixture is completely dissolved, and the layer is allowed to stand.Wash with 100 mL of water and de-dissolve to dryness to give an oil.That is, the original drug of cyhalofop-butyl ester 49.5g, the yield: 98.9%, the content: 98.0%,Optical 97.2%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Zhongqi Technology Co., Ltd.; Zhang Sheng; Zhang Pu; Wang Yuchi; Chen Wen; Wang Fengyun; Hou Yuanchang; (6 pag.)CN109651140; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts