In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2042-37-7 as follows. Recommanded Product: 2-Bromobenzonitrile
Preparation 6 A solution of 1.5M butyllithium in hexane (25 ml) in tetrahydrofuran (25 ml) was cooled at -78C by using dry ice-acetone bath under nitrogen atmosphere and a solution of 4-bromotoluene (6.40 g) in tetrahydrofuran (25 ml) was added dropwise to the solution. After being stirred at -78C for 1 hour, a solution of freshly fused zinc chloride (5.15 g) in tetrahydrofuran (25 ml) was added in a slow stream via cannula and the resulting mixture was allowed to warm to room temperature. The mixture was stirred at room temperature for 1 hour and the resulting solution was added to a solution of 2-bromobenzonitrile (4.55 g) and tetrakis(triphenylphosphine)palladium(0) (400 mg) in tetrahydrofuran (25 ml) at room temperature. The solution was stirred at room temperature overnight. The solution was diluted with ethyl acetate (300 ml) and washed successively with 1N-hydrochloric acid, water, and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography with a mixture of ethyl acetate and n-hexane (1:20) as eluent to give 2-cyano-4–methylbiphenyl (4.43 g) as white powders. mp: 44-47C NMR (CDCl3, delta): 2.42 (3H, s), 7.25-7.35 (2H, m), 7.35-7.5 (4H, m), 7.62 (1H, dt, J=1, 7.5Hz), 7.85 (1H, dd, J=1, 7.5Hz)
According to the analysis of related databases, 2042-37-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP426021; (1991); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts