Some common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 120351-94-2
Step 1 Synthesis of 3-[2-(2-naphthalenesulfonylamino)ethoxy]benzonitrile: 163 mg of 3-(2-aminoethoxy)benzonitrile and 0.5 ml of diisopropylethylamine were dissolved in 10 ml of dimethylformamide. A solution of 250 mg (1.1 mmol) of 2-naphthalenesulfonyl chloride in dimethylformamide was added to the obtained solution under cooling with ice, and they were stirred under cooling with ice for 2 hours. The title compound was obtained by the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant. Yield: 320 mg (0.91 mmol) (91 %) H-NMR (CDCl3) delta 3.45 (2H, dt), 4.00(2H, t), 5.05(1H, br), 6.96 (1H, s),6.97 (1H, d), 7.20 (1H, d), 7.30 (1H, t), 7.59-7.70 (2H, m), 7.82-7.98(4H, m), 8.46 (1H, s)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 120351-94-2, its application will become more common.
Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts