Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1897-52-5, name is 2,6-Difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2,6-Difluorobenzonitrile
To a solution of A3.l (500 g, 3.6 mol) in 2.5 L MeOH was added sodium methoxide (388 g, 7.2 mol) in portions slowly. The mixture was stirred at rt overnight. The reaction mixture was poured into 15 L H20 andthe precipitate was filtered off and washed twice with 2.0 L H20 to give the title compound (1140 g) as a white solid, the crude product will be used in next step without further purification. 1H NMR (500 MHz, CDCI3) O ppm 3.96 (5, 3H), 6.79 (dd, 2H), 7.52 (dd, 1H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1897-52-5.
Reference:
Patent; NOVARTIS AG; CHAN, Ho Man; FU, Xingnian; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue (Jeff); ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (148 pag.)WO2017/221100; (2017); A1;,
Nitrile – Wikipedia,
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