Reference of 1009-35-4, A common heterocyclic compound, 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, molecular formula is C7H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Before each run, the system (see Fig.4) was allowed to equilibrate by pumping solvent through for 30min with the Tube-in-Tube device at 16bar of hydrogen. An omnifit cartridge (20.0mm OD, 15.0mm ID) containing 1g of Pd-C catalyst was used. To avoid an overpressure of the system in the event of blockage, the upper pressure cut-off limit on the Knauer pump was set to 25bar. With the injection loop disconnected from the flow line, the loop was opened and filled manually (using a syringe) with 3.6mL of a 0.076M solution of starting material in ethanol (excess starting material solution exiting the loop was recovered for reuse). The injection loop was then closed off and switched into the flow stream. The outlet from the system (downstream of the back-pressure regulator) was collected for 120min. The solvent was removed under reduced pressure (using a rotary evaporator followed by a 2-stage rotary vane pump) to afford the product.
The synthetic route of 1009-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dimitriou, Eleni; Jones, Richard H.; Pritchard, Robin G.; Miller, Gavin J.; O’Brien, Matthew; Tetrahedron; vol. 74; 47; (2018); p. 6795 – 6803;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts