Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70591-86-5, name is 3-Bromobenzoylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H6BrNO
Intermediate 2 (0092) 3-(3-bromophenyl)-lH-pyrazol-5-amine A mixture of 3-(3-bromophenyl)-3- oxopropanenitrile (35 g, 156 mmol) and hydrazine hydrate (11.34 mL, 234 mmol) in ethanol (600 mL) was refluxed for 16 h. Mixture was then cooled and concentrated in vacuuo. Crude product was diluted with dichloromethane and stirred for 5 min. Solids were filtered and dried to afford 3-(3-bromophenyl)-lH-pyrazol-5-amine (30 g, 126 mmol, 81 % yield) as off-white solid. 1H NMR (400 MHz, DMSO-d6) delta 12.02 (br. s., 0.4H), 11.66 (br. s., 0.6H), 7.86 (t, J=1.6 Hz, 1H), 7.67 (d, J=7.5 Hz, 1H), 7.45 (d, J=6.8 Hz, 1H), 7.37 – 7.18 (m, 1H), 5.78 (br. s., 1H), 5.08 (br. s., 1.2H), 4.68 (br. s., 0.8H). LCMS (M+H) = 240.1.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 70591-86-5.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PEESE, Kevin; WANG, Zhongyu; LANGLEY, David, R.; KADOW, John, F.; NAIDU, Narasimhulu, B.; WO2015/123182; (2015); A1;,
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