Related Products of 53312-79-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53312-79-1, name is 3-Amino-4-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
j00316j A mixture of 3-amino-4-chlorobenzonitrile (1.0 g, 6.6 mmol) and potassium 0-ethyl carbonodithioate (2.1 g, 13.1 mmol) in 1-methylpyrrolidin-2-one (5 mL) at 25 C was degassed and purged with nitrogen 3 times. The mixture was stirred at 120 C for 10 hours, then poured into ice water (200 mL) and acidified with 1 mL concentrated hydrochloric acid, resulting in formation of a solid. The solid was collected by filtration, washed with water (3 x 10 mL) and dried in vacuo to give compound B-22 (1.1 g, crude) as a yellow solid, which was used directly without further purification. LCMS (B): tR=0.613 mi, (ES) mz (M+H) = 193.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-4-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts