In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H5F3N2
Step 2: 4- [2, 5-Dioxo-3-methyl-4-phenylimidazolidin-l-yl]-2-trifluoromethyl-benzonitrile; [00272] To a solution of 1.26 g of triphosgene in 20 mL of anhydrous toluene is added slowly a solution of 1.18 g of 4-amino-2-trifluoromethylbenzonitrile in 16 mL of anhydrous dioxan. The mixture is refluxed for 1.5 hour. After cooling at rt the mixture is evaporated to dryness. To this crude product diluted with 50 mL of anhydrous THF is added 1.13 g of methyl 2-methylamino-2-phenylacetate in 10 mL of THF. The mixture is stirred at rt for 30 min. 1.96 mL of TEA is added, the mixture is refluxed for 1.5 hour and stirred at rt for 16 h then evaporated to dryness. The crude product is diluted with an aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The organic phases are washed wiith water then brine, and dried over magnesium sulfate, filtered and evaporated. The crude product is crystallised in ethyl acetate, filtered and rinsed with ethyl ether to provide the desired product.TLC: Fr = 0.67 (dichloromethan/ethyl ether 90/10) delta 1H NMR (CDCl3): 3.06 (s, 3H); 5.06 (s, IH); 7.35-7.39 (m, 2H); 7.48-7.56 (m, 3H); 7.96 (d, IH); 8.03 (dd,IH); 8.18 (d, IH)LCMS : (rt = 2.91min, apolar method): not ionizable
The synthetic route of 654-70-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALAPAGOS NV; NIQUE, Francois; JAGERSCHMIDT, Catherine; BLANQUE, Roland; LEFRANCOIS, Jean-Michel; PEIXOTO, Christophe; DEPREZ, Pierre; TRIBALLEAU, Nicolas; WIGERINCK, Piet, Tom, Bert, Paul; NAMOUR, Florence, Sylvie; WO2010/29119; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts