These common heterocyclic compound, 6306-60-1, name is 2-(2,4-Dichlorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(2,4-Dichlorophenyl)acetonitrile
A suspension of sodium hydride (2.16 g) in dry dimethylsulphoxide (DMSO: 70 ml) was stirred at 50 C. under a nitrogen atmosphere for 2.5 hours and then cooled to 15 C. in an ice bath. A mixture of 2,4-dichlorophenylacetonitrile (8.37 g) and 3-methanesulphonyloxyhex-1-yl methanesulphonate (14.27 g) in DMSO (70 ml) was added dropwise to this solution over 15 minutes. The reaction mixture was stirred at room temperature for 0.5 hours, at 90 C. for 3 hours, and at 130 C. for 2 hours, and was then allowed to cool, diluted with water, and extracted with ether. The extracts were washed with water, dried over magnesium sulphate and concentrated to give a dark coloured oil (7.76 g). Purification of this crude product by bulb-to-bulb distillation gave a mixture of diastereomers of 1-cyano-1-(2,4-dichlorophenyl)-3-prop-1-ylcyclopentane (4.95 g, 39%) as a colourless oil (oven temperature: 230 C., ca. 10 torr).
The synthetic route of 2-(2,4-Dichlorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Imperial Chemical Industries Plc; US4684396; (1987); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts