Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327-74-2, name is 2-Amino-5-cyanobenzotrifluoride, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H5F3N2
General procedure: A solution of NaHCO3 (0.82 g) in distilled water (4 mL) was stirred for 10 minutes and to it was added DCM (4 mL) followed by the different aniline 7-10, 53 (2.4mmol). The reaction mixture was cooled to 0 C, thiophosgene (0.3 mL, 3.7 mmol) was added dropwise over 10 minutes and the reaction was then stirred at r.t. o.n. The mixture was then diluted with DCM (20 mL), washed with brine (20 mL), the organic layer was dried over Na2SO4 and concentrated to dryness. Aniline 9 (4.9 mmol) was dissolved in 9 mL toluene. Thiophosgene (10.67 mmol) was added dropwise and the mixture was stirred at 75 C for five days. Obtained in99% yield as a brown wax
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Bassetto, Marcella; Ferla, Salvatore; Pertusati, Fabrizio; Kandil, Sahar; Westwell, Andrew D.; Brancale, Andrea; McGuigan, Christopher; European Journal of Medicinal Chemistry; vol. 118; (2016); p. 230 – 243;,
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