A common compound: 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 939-80-0
TO a mixture of 4-chloro-3-nitro-benzonitrile (24.0 g, 131 mmol) and 3,5-dichloro-phenol (32.0 g, 197 mmol) in dry THF (150 ml) was added NaH (6.84 g, 171 mmol) in portions and the mixture was refluxed for 1 hour. After cooled to room temperature, the solvent was evaporated, and 100 ml of ice water and 20 ml of 4N NAOH aq. were added to the residue. The precipitate was collected by filtration, washed with 0.5 N NAOH aq. and water, dried in vacuo to give the 5-cyano-2- (3, 5-dichlorophenoxy) nitrobenzene (40.0 g, 98.4%) as slight yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 939-80-0, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER HEALTHCARE AG; WO2004/84898; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts