Synthetic Route of 31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
9.2 g of 4-nitrophthalonitrile, 5.0 g of phenol, 7.3 g of potassium carbonate and 40 ml of DMSO were added under the protection of an inert gas such as nitrogen, and the mixture was stirred at room temperature for 48 hours,The mixture was then heated to 60 C for 2 hours and then heated. After cooling, the mixture was precipitated and filtered to give a yellow solid which was dried to give 11.6 g of compound 1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BEIJING BETA PHARMA, INC.; (43 pag.)TWI582078; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts