In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 110301-23-0 as follows. HPLC of Formula: C7H4F2N2
Step 9 While stirring 420 cm3 of concentrated sulfuric acid on an ice water bath, 54 g (0.78 mol) of finely pulverized NaNO2 was added at a rate which maintained the temperature below 40 C. The mixture was stirred on a warm water bath at 50 C. until the crystals were completely dissolved. The solution was stirred on an ice water bath and 700 cm3 of glacial acetic acid was added drop-wise. 108 g (0.70 mol) of 4-amino-3,5-difluorobenzonitrile was added at a rate which maintained the temperature at 20-25 C. and the mixture was stirred at that temperature until the crystals were completely dissolved to form the corresponding diazonium salt. An aqueous solution of the diazonium salt was added drop-wise for 2 hours to a solution of 143 g (1.0 mol) of copper (I) bromide dissolved in 420 cm3 of 47% hydrobromic acid while stirring on an ice water bath. The resulting solution was stirred for one hour on an ice water bath and allowed to sit overnight at room temperature. The product was filtered, washed with glacial acetic acid and recrystallized from a solvent mixture of acetone and methanol to yield 98 g (0.45 mol) of 4-bromo-3,5-difluorobenzonitrile.
According to the analysis of related databases, 110301-23-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Seiko Epson Corporation; US5200110; (1993); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts