Electric Literature of 5922-60-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5922-60-1, name is 2-Amino-5-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Step 1 To a solution of (4-fluorophenyl)magnesium bromide (30 mL, 30 mmol) in anhydrous THF (15 mL) was added 2-amino-5-chloro-benzonitrile (1.53 g, 10.0 mmoL) portionwise at 0¡ã C. After the addition, the mixture was stirred at room temperature overnight. The reaction was quenched with 1 N HCl (30 mL) and reflux for 1 hr. The aqueous phase was extracted with DCM (30 mL*2). The extracts were dried over Na2SO4 and concentrated to dryness. The residue was purified by silica gel column (PE/EtOAc=10/1) to give (2-amino-5-chlorophenyl)(4-fluorophenyl)methanone (1.8 g, yield: 72percent) as a yellow solid. 1HNMR (400 MHz, DMSO-d6): delta=7.67 (dd, J=8.8, 5.2 Hz, 2H), 7.37 (d, J=2.8 Hz, 1H), 7.25 (dd, J=8.0, 2.4 Hz, 1H), 7.17 (d, J=8.4 Hz, 2H), 6.70 (d, J=8.8 Hz, 1H), 5.99 (brs, 2H).
The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-chlorobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sanford-Burnham Medical Research Institute; The Royal Institution for the Advancement of Learning / McGill University; The Government of the United States of America as Represented by the Secretary of the Department of; RONAI, Ze’ev; PINKERTON, Anthony B.; FENG, Yongmei; TOPISIROVIC, Ivan; BROWN, Kevin; HASSIG, Christian A.; (155 pag.)US2018/44324; (2018); A1;,
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